Size matters in drug delivery

first_imgCombining two strategies that are designed to improve the results of cancer treatment — angiogenesis inhibitors and nanomedicines — may only be successful if the smallest nanomedicines are used.A new study led by researchers at the Harvard School of Engineering and Applied Sciences (SEAS) and Massachusetts General Hospital (MGH) has found that normalizing blood vessels within tumors, which improves the delivery of standard chemotherapy drugs, can actually block the delivery of larger nanotherapy molecules.“We found that vascular normalization only increases the delivery of the smallest nanomedicines to cancer cells,” says lead author Vikash P. Chauhan, a graduate student in bioengineering at SEAS. “We also showed that the smallest nanomedicines are inherently better than larger nanomedicines at penetrating tumors, suggesting that smaller nanomedicines may be ideal for cancer therapy.”The results have been published in Nature Nanotechnology.Angiogenesis, the tumor-driven creation of new blood vessels, provides growing cancers with a food source — but it also provides a potential channel for drug delivery.The problem is that the vessels supplying tumors tend to be disorganized, oversized, and leaky. These abnormalities prevent the delivery of chemotherapy drugs to cells that are not close to the tumor vessels. The leakage of plasma out of blood vessels also increases pressure within the tumor, further reducing the drugs’ ability to penetrate the tissue. Fortunately, drugs that inhibit angiogenesis can reduce some of these problems in a process called vascular normalization.“Anti-angiogenic agents are prescribed to a large number of cancer patients in combination with conventional therapeutics,” explains principal investigator Rakesh K. Jain, Cook Professor of Radiation Oncology (Tumor Biology) at Harvard Medical School and director of the Steele Laboratory of Tumor Biology at MGH. Jain is also Chauhan’s Ph.D. adviser.The combination of standard chemotherapy drugs and normalization therapy has previously been shown to improve the effectiveness of treatment on some types of cancer.New nanomedicines, on the other hand, are designed to exploit the abnormality of tumor vessels. Nanomedicines, despite the name, are actually about 10 to 100 times larger than standard chemotherapy drugs — too large to penetrate the pores of blood vessels in normal tissues, but still small enough to pass through the oversized pores of tumor vessels. Because nanomedicines generally cannot penetrate normal tissues, they are expected to cause fewer side effects.The question in the Harvard-MGH study was whether vascular normalization would help or hinder the delivery of nanomedicines to tumors. The researchers found, through both theory and in vivo experimentation, that it depends on the size of the nanomedicines.Their mathematical model predicted that inhibiting angiogenesis would simultaneously reduce the size of the pores in the blood vessels and relieve pressure in the tumor, allowing small particles to penetrate.Confirming this experimentally in a mouse model of breast cancer, the investigators showed that vascular normalization (using an antibody called DC101) improved the penetration of 12-nanometer particles but not of 60- or 125-nanometer particles.They treated mice with implanted breast tumors either with DC101 and Doxil, a 100-nanometer version of the chemotherapy drug doxorubicin, or with DC101 and Abraxane, a 10-nanometer version of paclitaxel.  Although treatment with both chemotherapeutics delayed tumor growth, vascular normalization with DC101 improved the effectiveness only of Abraxane and had no effect on Doxil treatment.“A variety of anti-cancer nanomedicines are currently in use or in clinical trials,” says Chauhan, who completed the work at MGH.  “Our findings suggest that combining smaller nanomedicines with anti-angiogenic therapies may have a synergistic effect and that smaller nanomedicines should inherently penetrate tumors faster than larger nanomedicines, due to the physical principles that govern drug penetration. While it looks like future development of nanomedicines should focus on making them small — around 12 nanometers in size — we also need to investigate ways to improve delivery of the larger nanomedicines that are currently in use.”Additional co-authors of the Nature Nanotechnology report are Triantafyllos Stylianopoulos, John Martin, Walid Kamoun, and Dai Fukumura of MGH; and Zoran Popovic, Ou Chen, and Moungi Bawendi of the Massachusetts Institute of Technology (MIT).The work benefited from a long-term collaboration between Harvard, MGH, and MIT that explores the use of quantum dots as a biocompatible fluorescent marker in medical studies.Support for the study included grants from the National Institutes of Health and the Department of Defense.— Adapted from an earlier release by Sue McGreevey, Massachusetts General Hospital.last_img read more

Syracuse expects more than 31,000 fans for UNC game, asks crowd to arrive early

first_imgSyracuse is expecting more than 31,000 fans for the team’s game against North Carolina on Saturday at noon, SU Athletics announced on Friday.Fans are advised to arrive early and use ‘Print at Home’ tickets to save time entering the Carrier Dome. Traffic delays and large crowds outside entrances are expected near game time. Gates open at 10 a.m.There are still “a few thousand” tickets for sale at the Carrier Dome Box Office, according to SU Athletics spokesman Joe Giansante, including nearly a thousand unclaimed 3rd level/student section seats at $45 each. Giansante said there are also six floor seats remaining at $500 each.The No. 2 Orange (15-0, 2-0 Atlantic Coast) is facing the Tar Heels for only the eighth time in school history. SU is 3-4 all-time against North Carolina (10-5, 0-2), most recently defeating the then-No. 6 Tar Heels 87-71 in the 2K Sports Classic benefiting Coaches vs. Cancer at Madison Square on Nov. 20, 2009.The Carrier Dome has held 31,000 fans 53 times in men’s basketball history and 32,000 38 times. The venue held a record 35,012 for then-No. 8 SU’s 57-46 loss to No. 11 Georgetown on Feb. 23, 2013.AdvertisementThis is placeholder text Comments Facebook Twitter Google+ Published on January 10, 2014 at 12:48 pm Contact Stephen: [email protected] | @Stephen_Bailey1last_img read more

Chamber staff make women’s golf their business

first_img Staff at the Worcestershire and Herefordshire Chamber of Commerce have been getting into the swing to help more women and girls into golf. The Chamber has launched a new women’s participation programme as part of their Women’s Business Forums. And they have teamed up with Gaudet Luce Golf Club to offer special taster sessions. The club, which can be found in Middle Lane, Droitwich, is one of 100 clubs nationally taking part in an England Golf campaign to increase women’s participation. The golf and leisure complex is working with Mark Laing, Worcestershire county development officer, to forge new links in the community as well as creating an easy pathway into the sport and potential club membership for new players. Chamber staff have enjoyed a taste of what the programme offers – and now want to take the game further themselves. Organiser Natalie Tanner, Business Development Executive, said: “Nine women came on the event and really enjoyed it. Now, everybody plans to sign up for further Get into golf events.” Mark Laing says: “Working with partners to put on taster events like this really does help to break down the barriers to playing golf.” The event was advertised internally at the Chamber and nine women signed up for the two-hour evening at the club’s driving range. Most were completely new to the game. Natalie adds: “A few of the women were sceptical about whether they would be able to hit the ball, but they soon discovered they all could. “There can be a perception that it’s mainly men who mix golf and business, but the success of this taster event shows women are just as keen and love to play if they are given the opportunity.” The event with PGA professional Russell Adams covered golfing basics, such as how to stand, grip the club and hit the ball. It finished with a light-hearted competition to see who could hit the ball best using the skills they had just learnt. Other innovative ideas also included a special golf day for insolvency firm Poppleton and Appleby, who wanted to a novel way to engage with women to discuss their field of expertise. The greet and meet day included a warm-up session on the range with the club’s PGA professionals, a 9 hole Texas scramble on the par 3 course, a chat about golf, afternoon tea and networking. The idea was extended into a six-week coaching programme while the greet and meet day has been repeated for a local accountant and lawyer, with 60 people overall enjoying the taster sessions. Mark Laing says: “I have been using Gaudet Luce to pilot some of our projects before passing on what we have learnt to the other five clubs in the county involved.  These are Ombersley, The Vale, Kings Norton, Cleobury Mortimer and Kidderminster.” To find out more about the Get into golf campaign and how you can get started visit www.getintogolf.org or call 0800 118 2766 Get into golf is the national campaign to inspire adults to take up golf, run by England Golf and supported by Sport England National Lottery funding. Caption: Some of the Chamber staff at their after-work taster session (image © John Felix). Click here to view a short film showing how they had fun and learnt a new skill while unwinding at the event. 26 Oct 2015 Chamber staff make women’s golf their business last_img read more

Johnson meets Cotter in Canadian Direct Insurance A-Final Thursday at Nelson Curling Club

first_img“It’s kind of a new team that we put together and we haven’t played a lot together so we focused a lot in practice and his paying off in the game.”They did it the hard way, scoring single points in six ends to edge Craig.Trailing 5-4 with last rock in the tenth, Craig missed on is final attempt to give Johnson the win.Meanwhile, Cotter, third Ryan Kuhn, second Tyrel Griffiths and lead Rick Sawatsk continue to roll as the Okanagan rink dumped Glen Jackson of Victoria 7-4 in the other A semi final.Cotter scored consecutive points in the third, fourth and fifth ends — in the fifth the rink counted three — to open a 5-1 lead.Jackson scored a single in the sixth before stealing another point in the seventh but could never further cut into the Cotter lead.In B Event play, Kootenay Rep Chris Ducharme of Creston edged out Stephen Schneider of Vancouver 7-6 in 11 ends; Jeff Richard of Kelowna doubled Chase Martyn of New Westminster 10-5 and Daniel Wenzek of Langley sent pre-tournament favourite Joanisse to his second loss in as many games, 8-7.Action continues today with two draws at 2 and 7 p.m. Michael Johnson is betting against the odds, and winning.The underdog Victoria rink knocked off its second heavyweight at the 2016 Canadian Direct Insurance BC Men’s Curling Championships, outlasting club mate Wes Craig 6-4 during Thursday’s morning draw to advance into the A final tonight at 7 p.m.Wednesday, Johnson doubled another top rink, Dean Joanisse of New Westminster, 6-3.Johnson, third Chris Baier, second Ty Diello and lead Mitch Young hope to continue their mission against defending BC Champion Jim Cotter of Vernon.”We practiced a lot going into this event and I think it’s paying off on the ice,” Johnson said after the latest victory Thursday.last_img read more

Jeff Duling, Nov. 30

first_imgShare Facebook Twitter Google + LinkedIn Pinterest I am not putting too much emphasis on the test plots. I am just going with what my seed guy says. I will probably plant the same hybrids I planted last year. As far as beans, I had tremendous success with the Plenish beans again and so we’ll run with that. I am getting a 50-cent premium and the yields are right there with my other beans.I thought we would have some major compaction issues, and some guys do, but the dry weather and the cracking in the soil alleviated a lot of those problems. Maybe with the no-till and cover crops that was enough to help it out.I am hoping a few more guys experiment with cover crops. The government is throwing a lot of money at us to experiment with this. You can’t just do it once in one field and expect to see a benefit. In Putnam County now you have to keep it in cover crops for three years. The problem is that so many guys see their neighbors ripping and they think they should go rip. But this year, I didn’t see much reason to do much tillage.last_img read more

Opioid epidemic hits close to home in Ohio

first_imgShare Facebook Twitter Google + LinkedIn Pinterest Ohio now leads the nation in opioid-related overdose deaths with a record 4,050 drug overdose deaths reported in 2016, a 33% increase from 2015, according to the Ohio Department of Health. And, some 60% of those abusing or dependent on opioids in the state lack access to appropriate treatment, said Mark Partridge, chair of the C. William Swank Program in Rural-Urban Policy at The Ohio State University and professor in the Department of Agricultural, Environmental, and Development Economics.These unsettling statistics have encouraged Ohioans (rural, urban and everywhere in between) to ramp up the battle against the state’s devastating opioid epidemic. An event, “Hope for Ohio: A teen forum on the opioid crisis” will combine the efforts of Ohio State University Extension 4-H Healthy Living Advocates, Ohio Farm Bureau, Ohio FFA, and the Prevention Action Alliance on Saturday, Dec. 2, 2017 at the Nationwide & Ohio Farm Bureau 4-H Center. The event will take place 10 a.m. to 4:45 p.m. and the registration deadline is Nov. 22. The forum is designed to educate and prepare both teens and adults to take action against drug abuse in their communities. Highlights include a presentation from Tyler’s Light, a town hall with Ohio Legislators, and programming from Prevention Action Alliance. The day will conclude with an inspirational sendoff from David Kohout. Registration is online at https://ohio4h.org/events/hope-ohio-teen-forum-opioid-crisis and the cost is $10.According to a report recently released by researchers with the OSU Swank program, medication-assisted treatment is the most clinically effective and cost-efficient method for reducing opioid addiction, abuse and overdose death.“As it now stands, Ohio likely only has the capacity to treat 20 to 40% of the estimated 92,000 to 170,000 Ohioans who are abusing or dependent on opioids,” Partridge said. “Enacting new laws to take down pill mills and lessen access to prescription opioid drugs alone isn’t going to fix the problem. We need a broader-based approach that includes working with physicians and hospitals in underserved areas to encourage providers to obtain the waiver required to prescribe opioid treatments to their patients.“As it now stands, many people in rural areas of Ohio have extremely limited access to medication-assisted treatment, which is a particularly critical issue in the rural areas of southwest Ohio where opioid abuse rates are high, but local access to treatment is limited.”The 2017 analysis, Taking Measure of Ohio’s Opioid Crisis, is 22 pages and available to download free online at go.osu.edu/takingmeasure. The report says medication-assisted treatment has shown to be a clinically effective and cost-efficient approach to treating opioid addiction, with three common medications used in the treatment of opioid addition: methadone, buprenorphine and naltrexone.Yet, Ohio has only 26 certified methadone treatment centers and 377 doctors who are certified to prescribe buprenorphine.“It has been estimated that for every dollar spent on methadone and buprenorphine treatment, $1.80 in social savings would be realized,” said Mike Betz, report co-author and assistant professor in Ohio State’s Department of Human Sciences.Betz said there needs to be a shift in emphasis from stopping pill mills and over-prescribing to treating those already addicted to bring them into the mainstream and assist them in becoming more productive.“We need a two-pronged approach,” Betz said. “Treatment and a leg up economically through investments in the education, skills, physical health and mental health of Ohio citizens.”Opioid drugs, including prescription painkillers and heroin, killed more than 33,000 people nationwide in 2015, more than any year on record, according to the U.S. Centers for Disease Control and Prevention. There were 3,050 overdose deaths in Ohio in 2015, with 58.2% of the deaths blamed on the use of fentanyl and its derivatives, an opioid 50 times stronger than heroin, officials said.The annual cost of opiate abuse, addiction and overdoses to Ohio is estimated to be between $6.6 billion to $8.8 billion, the report said.Report co-author Mark Rembert puts the looming figure in perspective.“Our estimates suggest that the total social and economic costs of the opioid crisis are similar to what the state spends on K-12 education,” said Rembert, report co-author and co-founder of Energize Clinton County, a community economic development non-profit. “The opioid crisis is draining resources that could otherwise be used to support the economic development of the state.”Partridge said both attention and funding from the federal government are crucial in making a dent in the opioid abuse problem because states like Ohio are already too stretched.“A federal-state solution is key,” Partridge said. “The federal government has the resources and best practices necessary to tackle a public health and economic challenge of this magnitude.”Another key finding from the report is that there is a robust and direct correlation between unemployment rates and opiate overdoses and deaths. Individuals living in high-unemployment regions of the state tend to also have high levels of opioid abuse.“There is also a cumulative disadvantage,” said Bo Feng, a co-author of the report and a Swank research associate. “The longer people are unemployed, the more opiate abuse and overdoses occur.”Partridge said improving the labor market in hard-hit communities would help.“Middle- and lower-class families need sufficient incomes and stability,” Partridge said. “While that is a harder policy level to pull, it’s imperative to make any real change.”last_img read more

A U.S.-Made Door for Passivhaus Buildings

first_img In a video about the door, Palmer notes that European homes, including Passivhaus projects, typically use overlay doors, while homes in the U.S. usually feature inset doors. The H&H prototype, at 4 in. thick, conforms to the latter style, and is designed for a double-rabbet frame, with two layers of weatherstripping. The door is equipped with a four-point lock system featuring European-manufactured multipoint locks.H&H building energy analyst Skylar Swinford noted in an e-mail that the thermal resistance of the prototype door is about R-11, installed. The company also is working on another prototype that would feature Dow Corning vacuum insulated panels as an alternative to the polyisocyanurate, increasing the R-value at the center of the door to R-80 and the door assembly’s overall R-value to R-16. In addition, H&H will develop other options for the door frames – using over-insulated frames and low-conductivity thresholds, for example – to further boost the overall performance.Swinford adds that prices for the door start at $4,000 plus freight. The Karuna House balancing actThe Karuna House client and H&H are treating the project, begun in November 2011, as an extended case study for buildings that aim for two or more green certifications. So far, the Karuna design-and-build team has had to develop several work-arounds to accommodate materials requirements and/or prohibitions imposed by the certification programs. But the project still appears to be on track for all three. The development of the Passivhaus door adds an entrepreneurial dimension the Karuna experiment. Builder Hammer & Hand, based in Portland, Oregon, has developed a design and production strategy for exterior doors that conform to the Passivhaus performance standard.H&H’s march to the forefront of Passivhaus door making in the U.S. is driven by a few factors, including the growing adoption of the standard here and the fact that windows and exterior doors for many domestic Passivhaus projects typically are imported, at relatively high cost, from Europe. The materials for H&H’s Passivhaus door – including Forest Stewardship Council-certified clear vertical-grain Douglas fir, with a polyisocyanurate insulation core – are locally sourced, eliminating the expense and environmental cost of shipping from Europe.H&H’s workshop manager, Dan Palmer, led production of a prototype door that recently was installed on an H&H project called Karuna House, which is itself a prototype project in that it is designed to meet three stringent green building standards: Passivhaus, LEED for Homes Platinum, and Minergie-P-ECO. The project’s Minergie-P-ECO certification, in fact, is nearing completion.center_img RELATED ARTICLES Seeking an Affordable Energy-Efficient Exterior DoorNew Green Building Products — September 2011Energy-Efficient Garage DoorsGBA Product Guide: Drewexim Passive House DoorsGBA Product Guide: Intus Passive House DoorsGBA Product Guide: Pazen Fenstertechnik DoorsQ&A: Exterior doors that are well-insulated and seal well Brute Force Collaborative: Passivhaus Doors J.S. Benson: Passivhaus Doorslast_img read more

Groklaw Shuts Down, A Self-Described Casualty In The Privacy Wars

first_img8 Best WordPress Hosting Solutions on the Market You may not have heard of Pamela Jones, creator of the legal blog site known as Groklaw, but you may have heard of the legal case that she helped dismantle through patience, research and no small amount of moxie: the $1 billion lawsuit leveled at IBM by The SCO Group in 2003.Through that case, and the other SCO lawsuits that appeared on the docket in 2003-2004, Jones endured repeated attempts of exposure and no small amount of intimidation by The SCO Group or its proxies… but it would take something else entirely to drive Jones from the Internet once and for all.See also Death Before Dishonor: Secure Email Services Shut Down Rather Than Comply With FedsOn Groklaw today, Jones has announced that she is shutting down the site and removing herself from the Internet. The reason? Recent moves from private e-mail services like Lavabit and Secret Circle to shut down their businesses in order to protect customers from government surveillance.The owner of Lavabit tells us that he’s stopped using email and if we knew what he knew, we’d stop too.There is no way to do Groklaw without email. Therein lies the conundrum.Concerned that Groklaw’s email communications will be or could now be monitored, Jones has opted to end the work on the site entirely.I hope that makes it clear why I can’t continue. There is now no shield from forced exposure. Nothing in that parenthetical thought list is terrorism-related, but no one can feel protected enough from forced exposure any more to say anything the least bit like that to anyone in an email, particularly from the US out or to the US in, but really anywhere. You don’t expect a stranger to read your private communications to a friend. And once you know they can, what is there to say? Constricted and distracted. That’s it exactly. That’s how I feel.So. There we are. The foundation of Groklaw is over. I can’t do Groklaw without your input. I was never exaggerating about that when we won awards. It really was a collaborative effort, and there is now no private way, evidently, to collaborate.It might be a surprise to some that Jones would elect to take this option, rather than make a stand and fight, perhaps with Groklaw itself. The site used crowdsourced research and education to help dispel The SCO Group’s claims that as the owner of the copyright for the UNIX operating system, it was entitled to a licensing fee from any user of the Linux operating system, which SCO also claimed had copied code directly from UNIX.Those claims were never really settled because ultimately Novell would step forward and successfully challenge SCO’s copyright ownership of UNIX. It turns out that you can’t sue for something you don’t actually own, and SCO’s cases melted like snow on a hot summer’s day.Through the legal twists and turns of the SCO legal battles in 2005, odd efforts to disclaim Jones would occur. Many of her detractors claimed she was nothing more than an astroturfing front for IBM itself, claims which were made to me as a journalist . In 2005 Sys-Con reporter Maureen O’Gara attempted to track Jones down at her Hartsdale, NY home using, Jones claimed, private investigators to do the leg work the story. That story, later struck down by Sys-Con, painted a less-than-flattering picture of Jones and also appeared to use SCO-delivered clues to track the blogger down.In 2007, before the Novell case blew SCO’s claims out of the water, accusations that Jones—which may have always been a pen name for the Groklaw editor—was working for IBM came to a head. SCO attempted to serve Jones a subpoena for a deposition with an unknown reason, but the attempt was unsuccessful, according to then-Forbes writer and former ReadWrite Editor in Chief Dan Lyons. Jones claimed she would be taking a “health break” from the site and was unavailable at the time.Deserved or not, no one can deny that Jones has endured a lot of scrutiny in her tenure at Groklaw. After putting up with the deliberate attacks on her site and character, Jones has demonstrated that she is no wilting flower.But Jones is, by many accounts, a deeply private person. I have never met her in person, as she has kept her distance, preferring to communicate via e-mail over the years. People who have met her have repeatedly emphasized Jones’ need for personal privacy.With that in mind, then, Jones’ need to withdraw from the Internet, while frustrating for her and her readers, becomes a little more understandable. Jones has demonstrated a fierce capacity to fight for the law, but her Achilles’ heel has always been the need to protect her own private life and the work done behind the scenes at Groklaw. If the U.S. intelligence community is indeed taking steps to intercept e-mails in a non-targeted manner, then it is clear why Jones is stepping away: she cannot feel safe working in this medium any longer.My personal decision is to get off of the Internet to the degree it’s possible. I’m just an ordinary person. But I really know, after all my research and some serious thinking things through, that I can’t stay online personally without losing my humanness, now that I know that ensuring privacy online is impossible. I find myself unable to write. I’ve always been a private person. That’s why I never wanted to be a celebrity and why I fought hard to maintain both my privacy and yours.Oddly, if everyone did that, leap off the Internet, the world’s economy would collapse, I suppose. I can’t really hope for that. But for me, the Internet is over.Given all that Jones has had to put up with, her pulling away from the Internet now should serve as a signal to others that the actions of the U.S. intelligence services will have broad and far-reaching consequences on how much users should trust the Internet.The casualty of Groklaw may be among the first of many to fall in the privacy wars.Image courtesy of Shutterstock. Top Reasons to Go With Managed WordPress Hosting Tags:#nsa#privacy#spying A Web Developer’s New Best Friend is the AI Wai…center_img Related Posts brian proffitt Why Tech Companies Need Simpler Terms of Servic…last_img read more

Jameis Winston, Bryce Petty On Michigan’s Campus To Work With Jim Harbaugh

first_imgJim Harbaugh works with Jameis Winston ahead of draft.The Michigan Wolverines will certainly be looking for a solid quarterback ahead of the 2015 season, and unfortunately, they’ve got two on campus right now who aren’t eligible to suit up. Former Florida State signal-caller Jameis Winston and former Baylor quarterback Bryce Petty are in Ann Arbor to work with Jim Harbaugh ahead of the NFL Combine. The school tweeted a photo of the duo taking some advice from the new Wolverines head man.QBs Jameis Winston (FSU) & Bryce Petty (Baylor) are preparing for the NFL Combine at Schembechler Hall. pic.twitter.com/2ICM9XMVrc— Michigan Football (@umichfootball) February 17, 2015The NFL Combine takes place in Indianapolis, so perhaps the two are putting in some last-minute work ahead of time. So no, Michigan students, if you think you’ve seen either of these guys on campus, your eyes are not deceiving you.last_img read more

Additional Performers Added To Concert For America Stand Up Sing Out

first_imgConcert for America: Stand Up, Sing Out! has announced the full cast of artists and creators who will perform at the first concert of the monthly series, taking place today, January 20th, at The Town Hall in New York City at 3:00pm EST.The sold-out show – created and produced by Seth Rudetsky and James Wesley – will feature performances and appearances by Betty Buckley, Michelle Collins, Lilla Crawford, Brian d’Arcy James, Sharon Gless, Judy Gold, Richard Kind, Judy Kuhn, Anika Larsen, Liz Larsen, Caissie Levy, Beth Malone, Carrie Manolakos, Stephanie Mills, Jessie Mueller, Kate Mulgrew, Julia Murney, Bebe Neuwirth, Kelli O’Hara, Piper Perabo, Rosie Perez, Billy Porter, Randy Rainbow, Caroline Rhea, Alice Ripley, Chita Rivera, Shayna Steele, Brian Stokes Mitchell, Ben Vereen, Lillias White, Betsy Wolfe and more.For those who cannot attend, concerts of the monthly series will be live streamed on Concert4America2017.org. The broadcast will be directed by Emmy Award winner Debbie Miller.Proceeds benefit several national organizations working to protect human rights, including the NAACP, Planned Parenthood, Southern Poverty Law Center, National Immigration Law Center, and Sierra Club Foundation. Cornell William Brooks, President and CEO of the NAACP, will attend the concert and be a featured speaker as part of Friday’s program.Concert for America: Stand Up, Sing Out! is created and organized by Seth Rudetsky and James Wesley in association with Your Kids, Our Kids with the support of Broadway Cares/Equity Fights AIDS. Additional concert locations for the Concert for America: Stand Up, Sing Out! series will be announced in the coming weeks.last_img read more